MdePkg[all]  1.08
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gEfiI2cMasterProtocolGuid

Include/Protocol/I2cMaster.h

PROTOCOL Information

PROTOCOL's Guid NamePROTOCOL's Guid
gEfiI2cMasterProtocolGuid{ 0xcd72881f, 0x45b5, 0x4feb, { 0x98, 0xc8, 0x31, 0x3d, 0xa8, 0x11, 0x74, 0x62 }}

Refer to Header File

MdePkg/Include/Protocol/I2cMaster.h