MdePkg[all]  1.08
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gEfiI2cIoProtocolGuid

Include/Protocol/I2cIo.h

PROTOCOL Information

PROTOCOL's Guid NamePROTOCOL's Guid
gEfiI2cIoProtocolGuid{ 0xb60a3e6b, 0x18c4, 0x46e5, { 0xa2, 0x9a, 0xc9, 0xa1, 0x06, 0x65, 0xa2, 0x8e }}

Refer to Header File

MdePkg/Include/Protocol/I2cIo.h