MdePkg[all]  1.08
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gEfiI2cHostProtocolGuid

Include/Protocol/I2cHost.h

PROTOCOL Information

PROTOCOL's Guid NamePROTOCOL's Guid
gEfiI2cHostProtocolGuid{ 0xa5aab9e3, 0xc727, 0x48cd, { 0x8b, 0xbf, 0x42, 0x72, 0x33, 0x85, 0x49, 0x48 }}

Refer to Header File

MdePkg/Include/Protocol/I2cHost.h